8IM2

Crystal structure of human HPPD complexed with NTBC

8IM2 の概要

• エントリーDOI: 10.2210/pdb8im2/pdb
• 分子名称: 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION, 2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE, ... (5 entities in total)
• 機能のキーワード: enzyme, inhibitor, complex, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 273015.51

構造登録者

Dong, J.,Lin, H.-Y.,Yang, G.-F. (登録日: 2023-03-05, 公開日: 2023-10-18, 最終更新日: 2023-12-27)

• 主引用文献: Dong, J.,Xiao, H.,Chen, J.N.,Zheng, B.F.,Xu, Y.L.,Chen, M.X.,Yang, W.C.,Lin, H.Y.,Yang, G.F.; Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors.; Structure, 31:1604-, 2023; PubMed: 37794595; DOI: 10.1016/j.str.2023.09.005

実験手法

X-RAY DIFFRACTION (2.81 Å)