8I7X
Crystal structure of human ClpP in complex with ZG36
Summary for 8I7X
Entry DOI | 10.2210/pdb8i7x/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, mitochondrial, (6S,9aS)-N-[(4-bromophenyl)methyl]-6-[(2S)-butan-2-yl]-8-[(4-methoxynaphthalen-1-yl)methyl]-4,7-bis(oxidanylidene)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide (3 entities in total) |
Functional Keywords | mitochondrial protease, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 14 |
Total formula weight | 347164.30 |
Authors | Wang, P.Y.,Gan, J.H.,Yang, C.-G. (deposition date: 2023-02-02, release date: 2023-07-19, Last modification date: 2024-05-29) |
Primary citation | Zhang, R.,Wang, P.,Wei, B.,Chen, L.,Song, X.,Pan, Y.,Li, J.,Gan, J.,Zhang, T.,Yang, C.G. Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists. Eur.J.Med.Chem., 258:115577-115577, 2023 Cited by PubMed: 37352796DOI: 10.1016/j.ejmech.2023.115577 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
Download full validation report