8I7X

Crystal structure of human ClpP in complex with ZG36

Summary for 8I7X

• Entry DOI: 10.2210/pdb8i7x/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, (6S,9aS)-N-[(4-bromophenyl)methyl]-6-[(2S)-butan-2-yl]-8-[(4-methoxynaphthalen-1-yl)methyl]-4,7-bis(oxidanylidene)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide (3 entities in total)
• Functional Keywords: mitochondrial protease, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 14
• Total formula weight: 347164.30

Authors

Wang, P.Y.,Gan, J.H.,Yang, C.-G. (deposition date: 2023-02-02, release date: 2023-07-19, Last modification date: 2024-05-29)

• Primary citation: Zhang, R.,Wang, P.,Wei, B.,Chen, L.,Song, X.,Pan, Y.,Li, J.,Gan, J.,Zhang, T.,Yang, C.G.; Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists.; Eur.J.Med.Chem., 258:115577-115577, 2023; PubMed: 37352796; DOI: 10.1016/j.ejmech.2023.115577

Experimental method

X-RAY DIFFRACTION (1.99 Å)