8I66
Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with isoorotic acid (2,4-Dihydroxypyrimidine-5-carboxylic Acid) and citric acid, Form I
Summary for 8I66
Entry DOI | 10.2210/pdb8i66/pdb |
Descriptor | Uracil-DNA glycosylase, 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, CITRIC ACID, ... (4 entities in total) |
Functional Keywords | dna repair, base excision repair, inhibitor-complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 1 |
Total formula weight | 26161.76 |
Authors | |
Primary citation | Kesharwani, S.,Raj, P.,Paul, A.,Roy, K.,Bhanot, A.,Mehta, A.,Gopal, A.,Varshney, U.,Gopal, B.,Sundriyal, S. Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment Eur.J.Med.Chem., 258:115604-, 2023 Cited by DOI: 10.1016/j.ejmech.2023.115604PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report