8I66

Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with isoorotic acid (2,4-Dihydroxypyrimidine-5-carboxylic Acid) and citric acid, Form I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Uracil-DNA glycosylase	polymer	238	25813.5	1	UniProt (P9WFQ9) Pfam (PF03167)	Mycobacterium tuberculosis H37Rv	UDG
2	B (A)	2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid	non-polymer		156.1	1	Chemie (5CU)
3	C (A)	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
4	D (A)	water	water		18.0	36	Chemie (HOH)

Sequence modifications

A: 1 - 227 (UniProt: P9WFQ9)

PDB	External Database	Details
Met -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	25813.5
Non-Polymers*	Number of molecules	2
	Total formula weight	348.2
All*	Total formula weight	26161.8

*Water molecules are not included.