8HYI

Crystal structure of human P-cadherin MEC12 (X dimer) in complex with 2-(2-methyl-5-phenyl-1H-indole-3-yl)ethan-1-amine

Summary for 8HYI

Entry DOI	10.2210/pdb8hyi/pdb
Descriptor	Cadherin-3, 2-(2-methyl-5-phenyl-1H-indole-3-yl)ethan-1-amine, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	inhibitor, cell adhesion
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	47741.43
Authors	Senoo, A.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K. (deposition date: 2023-01-06, release date: 2023-08-30, Last modification date: 2023-10-11)
Primary citation	Senoo, A.,Nagatoishi, S.,Kuroda, D.,Ito, S.,Ueno, G.,Caaveiro, J.M.M.,Tsumoto, K. Modulation of a conformational ensemble by a small molecule that inhibits key protein-protein interactions involved in cell adhesion. Protein Sci., 32:e4744-e4744, 2023 Cited by PubMed: 37531208 DOI: 10.1002/pro.4744 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation