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8HUO

X-ray structure of human PPAR delta ligand binding domain-seladelpar co-crystals obtained by co-crystallization

Summary for 8HUO
Entry DOI10.2210/pdb8huo/pdb
DescriptorPeroxisome proliferator-activated receptor delta, Seladelpar (2 entities in total)
Functional Keywordsnuclear receptor, protein-ligand complex, ppar, transcription
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight63944.23
Authors
Kamata, S.,Honda, A.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Masuda, R.,Oyama, T.,Ishii, I. (deposition date: 2022-12-24, release date: 2023-08-09, Last modification date: 2023-09-06)
Primary citationKamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Fujita, A.,Kaneko, C.,Miyawaki, S.,Habu, Y.,Shiiyama, Y.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I.
Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor.
Antioxidants, 12:-, 2023
Cited by
PubMed: 37627519
DOI: 10.3390/antiox12081523
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.671 Å)
Structure validation

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