8HO4
Falcilysin in complex with MMV000848
Summary for 8HO4
Entry DOI | 10.2210/pdb8ho4/pdb |
Descriptor | Falcilysin, (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | falcilysin, mmv000848, inhibitor, complex, protein binding, hydrolase |
Biological source | Plasmodium falciparum 3D7 |
Total number of polymer chains | 1 |
Total formula weight | 135599.39 |
Authors | Lin, J.Q.,Chung, Z.,Lescar, J. (deposition date: 2022-12-09, release date: 2023-12-20, Last modification date: 2024-07-03) |
Primary citation | Wirjanata, G.,Lin, J.,Dziekan, J.M.,El Sahili, A.,Chung, Z.,Tjia, S.,Binte Zulkifli, N.E.,Boentoro, J.,Tham, R.,Jia, L.S.,Go, K.D.,Yu, H.,Partridge, A.,Olsen, D.,Prabhu, N.,Sobota, R.M.,Nordlund, P.,Lescar, J.,Bozdech, Z. Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development. Cell Chem Biol, 31:743-759.e8, 2024 Cited by PubMed: 38593807DOI: 10.1016/j.chembiol.2024.03.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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