8HNT
Crystal structure of anti-CRISPR protein AcrIIC4 bound to HpaCas9-sgRNA surveillance complex
Summary for 8HNT
Entry DOI | 10.2210/pdb8hnt/pdb |
Descriptor | CRISPR-associated endonuclease Cas9, sgRNA, anti-CRISPR protein AcrIIC4 (3 entities in total) |
Functional Keywords | cas9, antimicrobial protein, rec lobe, immune system |
Biological source | Haemophilus parainfluenzae More |
Total number of polymer chains | 3 |
Total formula weight | 172649.29 |
Authors | |
Primary citation | Sun, W.,Cheng, Z.,Wang, J.,Yang, J.,Li, X.,Wang, J.,Chen, M.,Yang, X.,Sheng, G.,Lou, J.,Wang, Y. AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA, 120:e2303675120-e2303675120, 2023 Cited by PubMed: 37494395DOI: 10.1073/pnas.2303675120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.06 Å) |
Structure validation
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