8HHQ

Covalent bond formation between cysteine of PPARg-LBD and iodoacetic acid

Summary for 8HHQ

Entry DOI	10.2210/pdb8hhq/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, GLYCOLIC ACID (3 entities in total)
Functional Keywords	pparg-lbd, iodoacetic acid, cysteine, covalent modifier, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	63051.14
Authors	Kojima, H.,Itoh, T. (deposition date: 2022-11-16, release date: 2023-09-20, Last modification date: 2023-11-15)
Primary citation	Kojima, H.,Yanagi, R.,Higuchi, E.,Yoshizawa, M.,Shimodaira, T.,Kumagai, M.,Kyoya, T.,Sekine, M.,Egawa, D.,Ohashi, N.,Ishida, H.,Yamamoto, K.,Itoh, T. Covalent Modifier Discovery Using Hydrogen/Deuterium Exchange-Mass Spectrometry. J.Med.Chem., 66:4827-4839, 2023 Cited by PubMed: 36994595 DOI: 10.1021/acs.jmedchem.2c01986 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation