8H73

Crystal structure of antibody scFv against M2e Influenza peptide

Summary for 8H73

Entry DOI	10.2210/pdb8h73/pdb
Related	8H3B
Descriptor	Single Chain Variable Fragment, CITRATE ANION (3 entities in total)
Functional Keywords	scfv, antiviral protein
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	26945.78
Authors	Kumar, U.,Madni, Z.K.,Gaur, V.,Salunke, D.M. (deposition date: 2022-10-18, release date: 2023-08-02, Last modification date: 2024-10-23)
Primary citation	Kumar, U.,Goyal, P.,Madni, Z.K.,Kamble, K.,Gaur, V.,Rajala, M.S.,Salunke, D.M. A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein. J.Biomed.Sci., 30:56-56, 2023 Cited by PubMed Abstract: The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transmembrane viral M2 proton ion channel. M2 ectodomain (M2e) is a potential universal candidate for monoclonal antibody therapy owing to its conserved nature across influenza virus subtypes and its importance in viral propagation. PubMed: 37491224 DOI: 10.1186/s12929-023-00950-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation