8GZ5
Crystal structure of neutralizing VHH P17 in complex with SARS-CoV-2 Alpha variant spike receptor-binding domain
Summary for 8GZ5
Entry DOI | 10.2210/pdb8gz5/pdb |
Descriptor | Spike protein S1, Nanobody P17, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | sars-cov-2, spike rbd, nanobody, vhh, viral protein, viral protein-immune system complex, viral protein/immune system |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) More |
Total number of polymer chains | 2 |
Total formula weight | 38262.58 |
Authors | Yamaguchi, K.,Anzai, I.,Maeda, R.,Moriguchi, M.,Watanabe, T.,Imura, A.,Takaori-Kondo, A.,Inoue, T. (deposition date: 2022-09-25, release date: 2022-12-07, Last modification date: 2023-11-29) |
Primary citation | Yamaguchi, K.,Anzai, I.,Maeda, R.,Moriguchi, M.,Watanabe, T.,Imura, A.,Takaori-Kondo, A.,Inoue, T. Structural insights into the rational design of a nanobody that binds with high affinity to the SARS-CoV-2 spike variant. J.Biochem., 173:115-127, 2023 Cited by PubMed: 36413757DOI: 10.1093/jb/mvac096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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