8GZ5

Crystal structure of neutralizing VHH P17 in complex with SARS-CoV-2 Alpha variant spike receptor-binding domain

8GZ5 の概要

• エントリーDOI: 10.2210/pdb8gz5/pdb
• 分子名称: Spike protein S1, Nanobody P17, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: sars-cov-2, spike rbd, nanobody, vhh, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38262.58

構造登録者

Yamaguchi, K.,Anzai, I.,Maeda, R.,Moriguchi, M.,Watanabe, T.,Imura, A.,Takaori-Kondo, A.,Inoue, T. (登録日: 2022-09-25, 公開日: 2022-12-07, 最終更新日: 2023-11-29)

• 主引用文献: Yamaguchi, K.,Anzai, I.,Maeda, R.,Moriguchi, M.,Watanabe, T.,Imura, A.,Takaori-Kondo, A.,Inoue, T.; Structural insights into the rational design of a nanobody that binds with high affinity to the SARS-CoV-2 spike variant.; J.Biochem., 173:115-127, 2023; PubMed: 36413757; DOI: 10.1093/jb/mvac096

実験手法

X-RAY DIFFRACTION (1.7 Å)