8GY7
Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein
Summary for 8GY7
Entry DOI | 10.2210/pdb8gy7/pdb |
EMDB information | 34371 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-3,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | melanocortin-2 receptor, mrap1, gpcr, acth, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 180141.73 |
Authors | Luo, P.,Feng, W.B.,Ma, S.S.,Dai, A.T.,Yuan, Q.N.,Wu, K.,Yang, D.H.,Wang, M.W.,Xu, H.E.,Jiang, Y. (deposition date: 2022-09-21, release date: 2023-01-11) |
Primary citation | Luo, P.,Feng, W.,Ma, S.,Dai, A.,Wu, K.,Chen, X.,Yuan, Q.,Cai, X.,Yang, D.,Wang, M.W.,Eric Xu, H.,Jiang, Y. Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1. Cell Res., 33:46-54, 2023 Cited by PubMed: 36588120DOI: 10.1038/s41422-022-00751-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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