8GTG
Corticotropin-releasing hormone receptor 1(CRF1R) bound with BMK-I-152 by XFEL
Summary for 8GTG
Entry DOI | 10.2210/pdb8gtg/pdb |
Descriptor | Isoform CRF-R2 of Corticotropin-releasing factor receptor 1, Endolysin, 8-(4-bromanyl-2,6-dimethoxy-phenyl)-~{N},~{N}-bis(2-methoxyethyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-amine (3 entities in total) |
Functional Keywords | membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 51293.44 |
Authors | |
Primary citation | Kim, H.,Lim, T.,Ha, G.E.,Lee, J.Y.,Kim, J.W.,Chang, N.,Kim, S.H.,Kim, K.H.,Lee, J.,Cho, Y.,Kim, B.W.,Abrahamsson, A.,Kim, S.H.,Kim, H.J.,Park, S.,Lee, S.J.,Park, J.,Cheong, E.,Kim, B.M.,Cho, H.S. Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser. Exp.Mol.Med., 55:2039-2050, 2023 Cited by PubMed: 37653040DOI: 10.1038/s12276-023-01082-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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