8GTG

Corticotropin-releasing hormone receptor 1(CRF1R) bound with BMK-I-152 by XFEL

Summary for 8GTG

• Entry DOI: 10.2210/pdb8gtg/pdb
• Descriptor: Isoform CRF-R2 of Corticotropin-releasing factor receptor 1, Endolysin, 8-(4-bromanyl-2,6-dimethoxy-phenyl)-~{N},~{N}-bis(2-methoxyethyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-amine (3 entities in total)
• Functional Keywords: membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 51293.44

Authors

Cho, H.S.,Kim, H. (deposition date: 2022-09-08, release date: 2023-09-13, Last modification date: 2023-10-18)

• Primary citation: Kim, H.,Lim, T.,Ha, G.E.,Lee, J.Y.,Kim, J.W.,Chang, N.,Kim, S.H.,Kim, K.H.,Lee, J.,Cho, Y.,Kim, B.W.,Abrahamsson, A.,Kim, S.H.,Kim, H.J.,Park, S.,Lee, S.J.,Park, J.,Cheong, E.,Kim, B.M.,Cho, H.S.; Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser.; Exp.Mol.Med., 55:2039-2050, 2023; PubMed: 37653040; DOI: 10.1038/s12276-023-01082-1

Experimental method

X-RAY DIFFRACTION (2.75 Å)