8GTG
Corticotropin-releasing hormone receptor 1(CRF1R) bound with BMK-I-152 by XFEL
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Isoform CRF-R2 of Corticotropin-releasing factor receptor 1 | polymer | 284 | 32685.4 | 1 | UniProt (P34998-2) Pfam (PF00002) UniProt (by SIFTS) (P34998) In PDB | Homo sapiens (human) | CRF-R-1,CRF-R1,CRFR-1,Corticotropin-releasing hormone receptor 1,CRH-R-1,CRH-R1 |
2 | B | Endolysin | polymer | 160 | 18113.7 | 1 | UniProt (A0A346FJK3) Pfam (PF00959) In PDB | Enterobacteria phage T6 | Lysis protein,Lysozyme,Muramidase |
3 | A | 8-(4-bromanyl-2,6-dimethoxy-phenyl)-~{N},~{N}-bis(2-methoxyethyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-amine | non-polymer | 494.4 | 1 | Chemie (CW9) |
Sequence modifications
A: 104 - 373 (UniProt: P34998-2)
B: 1000 - 1159 (UniProt: A0A346FJK3)
PDB | External Database | Details |
---|---|---|
Met 103 | - | initiating methionine |
Ala 120 | Val 120 | engineered mutation |
Ala 144 | Leu 144 | engineered mutation |
Ala 156 | Trp 156 | engineered mutation |
Ala 160 | Ser 160 | engineered mutation |
Ala 228 | Lys 228 | engineered mutation |
Ala 260 | Phe 260 | engineered mutation |
Ala 277 | Ile 277 | engineered mutation |
Ala 309 | Tyr 309 | engineered mutation |
Ala 330 | Phe 330 | engineered mutation |
Ala 349 | Ser 349 | engineered mutation |
Ala 363 | Tyr 363 | engineered mutation |
Ala 374 | - | expression tag |
Ala 375 | - | expression tag |
Ala 376 | - | expression tag |
His 377 | - | expression tag |
His 378 | - | expression tag |
His 379 | - | expression tag |
His 380 | - | expression tag |
His 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
His 385 | - | expression tag |
His 386 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 1052 | Cys 54 | engineered mutation |
Ser 1095 | Cys 97 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 50799.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 494.4 | |
All* | Total formula weight | 51293.4 |