8GT9
Selective targeting of the Beclin 2-Atg14L coiled coil complex by stapled peptides promotes autophagy and endolysosomal trafficking of GPCRs
Summary for 8GT9
Entry DOI | 10.2210/pdb8gt9/pdb |
Descriptor | Beclin-2 (2 entities in total) |
Functional Keywords | pi3kc3 complex, beclin 2, autophagy, structural protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 43883.68 |
Authors | |
Primary citation | Qiu, X.,Li, N.,Yang, Q.,Wu, S.,Li, X.,Pan, X.,Yamamoto, S.,Zhang, X.,Zeng, J.,Liao, J.,He, C.,Wang, R.,Zhao, Y. The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs. Autophagy, 19:2884-2898, 2023 Cited by PubMed: 37409929DOI: 10.1080/15548627.2023.2233872 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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