8GRH

Crystal structure of a constitutively active mutant of the alpha gamma heterodimer of human IDH3 in complex with CIT

Summary for 8GRH

Entry DOI	10.2210/pdb8grh/pdb
Descriptor	Human IDH3 alpha subunit, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, CITRIC ACID, ... (4 entities in total)
Functional Keywords	isocitrate dehydrogenase, nad-dependent idh, assembly, allosteric regulation, oxidoreductase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	75684.77
Authors	Sun, P.,Chen, X.,Ding, J. (deposition date: 2022-09-01, release date: 2022-11-30, Last modification date: 2023-11-29)
Primary citation	Chen, X.,Sun, P.,Liu, Y.,Shen, S.,Ma, T.,Ding, J. Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction. J.Biol.Chem., 298:102695-102695, 2022 Cited by PubMed: 36375638 DOI: 10.1016/j.jbc.2022.102695 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.506 Å)

Structure validation