8GKF
Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.
Summary for 8GKF
Entry DOI | 10.2210/pdb8gkf/pdb |
Descriptor | 4'-phosphopantetheinyl transferase PptT, TOMUDEX (3 entities in total) |
Functional Keywords | complex, inhibitor, drug, structural genomics, tb structural genomics consortium, tbsgc, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 9 |
Total formula weight | 235070.63 |
Authors | Krieger, I.V.,Singh, A.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2023-03-18, release date: 2024-03-20, Last modification date: 2024-03-27) |
Primary citation | Singh, A.,Ottavi, S.,Krieger, I.,Planck, K.,Perkowski, A.,Kaneko, T.,Davis, A.M.,Suh, C.,Zhang, D.,Goullieux, L.,Alex, A.,Roubert, C.,Gardner, M.,Preston, M.,Smith, D.M.,Ling, Y.,Roberts, J.,Cautain, B.,Upton, A.,Cooper, C.B.,Serbina, N.,Tanvir, Z.,Mosior, J.,Ouerfelli, O.,Yang, G.,Gold, B.S.,Rhee, K.Y.,Sacchettini, J.C.,Fotouhi, N.,Aube, J.,Nathan, C. Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase. Sci Adv, 10:eadj6406-eadj6406, 2024 Cited by PubMed: 38489355DOI: 10.1126/sciadv.adj6406 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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