8GKF

Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.

8GKF の概要

• エントリーDOI: 10.2210/pdb8gkf/pdb
• 分子名称: 4'-phosphopantetheinyl transferase PptT, TOMUDEX (3 entities in total)
• 機能のキーワード: complex, inhibitor, drug, structural genomics, tb structural genomics consortium, tbsgc, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 235070.63

構造登録者

Krieger, I.V.,Singh, A.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (登録日: 2023-03-18, 公開日: 2024-03-20, 最終更新日: 2024-03-27)

• 主引用文献: Singh, A.,Ottavi, S.,Krieger, I.,Planck, K.,Perkowski, A.,Kaneko, T.,Davis, A.M.,Suh, C.,Zhang, D.,Goullieux, L.,Alex, A.,Roubert, C.,Gardner, M.,Preston, M.,Smith, D.M.,Ling, Y.,Roberts, J.,Cautain, B.,Upton, A.,Cooper, C.B.,Serbina, N.,Tanvir, Z.,Mosior, J.,Ouerfelli, O.,Yang, G.,Gold, B.S.,Rhee, K.Y.,Sacchettini, J.C.,Fotouhi, N.,Aube, J.,Nathan, C.; Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.; Sci Adv, 10:eadj6406-eadj6406, 2024; PubMed: 38489355; DOI: 10.1126/sciadv.adj6406

実験手法

X-RAY DIFFRACTION (2.45 Å)