8GJU

Crystal structure of human methylmalonyl-CoA mutase (MMUT) in complex with methylmalonic acidemia type A protein (MMAA), coenzyme A, and GDP

Summary for 8GJU

• Entry DOI: 10.2210/pdb8gju/pdb
• Descriptor: Methylmalonic aciduria type A protein, mitochondrial, Methylmalonyl-CoA mutase, mitochondrial, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: protein-protein complex, isomerase, gtpase, g-protein, cobalamin, vitamin b12, transport, organometallic cofactor, isomerase-hydrolase complex, isomerase/hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 491855.50

Authors

Mascarenhas, R.M.,Ruetz, M.,Gouda, H.,Yaw, M.,Banerjee, R. (deposition date: 2023-03-16, release date: 2023-08-09, Last modification date: 2024-05-22)

• Primary citation: Mascarenhas, R.,Ruetz, M.,Gouda, H.,Heitman, N.,Yaw, M.,Banerjee, R.; Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B 12 delivery and repair.; Nat Commun, 14:4332-4332, 2023; PubMed: 37468522; DOI: 10.1038/s41467-023-40077-4

Experimental method

X-RAY DIFFRACTION (2.79 Å)