8GJU
Crystal structure of human methylmalonyl-CoA mutase (MMUT) in complex with methylmalonic acidemia type A protein (MMAA), coenzyme A, and GDP
Summary for 8GJU
Entry DOI | 10.2210/pdb8gju/pdb |
Descriptor | Methylmalonic aciduria type A protein, mitochondrial, Methylmalonyl-CoA mutase, mitochondrial, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | protein-protein complex, isomerase, gtpase, g-protein, cobalamin, vitamin b12, transport, organometallic cofactor, isomerase-hydrolase complex, isomerase/hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 491855.50 |
Authors | Mascarenhas, R.M.,Ruetz, M.,Gouda, H.,Yaw, M.,Banerjee, R. (deposition date: 2023-03-16, release date: 2023-08-09, Last modification date: 2024-05-22) |
Primary citation | Mascarenhas, R.,Ruetz, M.,Gouda, H.,Heitman, N.,Yaw, M.,Banerjee, R. Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B 12 delivery and repair. Nat Commun, 14:4332-4332, 2023 Cited by PubMed: 37468522DOI: 10.1038/s41467-023-40077-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
Download full validation report