8GF8

Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids

8GF8 の概要

• エントリーDOI: 10.2210/pdb8gf8/pdb
• 関連するPDBエントリー: 8GF9 8GFA
• EMDBエントリー: 29981 29982 29983
• 分子名称: Transient receptor potential cation channel subfamily V member 1, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, ... (4 entities in total)
• 機能のキーワード: transient receptor potential v family member 1, vanilloid, trp, apo, human, channel, trpv1, trp channels, pain, membrane protein, cnw11, nanodiscs, thermo-trp, temperature sensation
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 529178.39

構造登録者

Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (登録日: 2023-03-07, 公開日: 2023-05-10)

• 主引用文献: Neuberger, A.,Oda, M.,Nikolaev, Y.A.,Nadezhdin, K.D.,Gracheva, E.O.,Bagriantsev, S.N.,Sobolevsky, A.I.; Human TRPV1 structure and inhibition by the analgesic SB-366791.; Nat Commun, 14:2451-2451, 2023; PubMed: 37117175; DOI: 10.1038/s41467-023-38162-9

実験手法

ELECTRON MICROSCOPY (2.9 Å)