8GEY

Crystal structure of human cellular retinol binding protein 1 in complex with 4-(hydroxymethyl)-1-[(4-methoxy-5,6,7,8-tetrahydronaphthalen-1-yl)sulfonyl]piperidin-4-ol

8GEY の概要

• エントリーDOI: 10.2210/pdb8gey/pdb
• 関連するPDBエントリー: 8GD2 8GDM 8GEM 8GEU 8GEV
• 分子名称: Retinol-binding protein 1, 4-(hydroxymethyl)-1-(4-methoxy-5,6,7,8-tetrahydronaphthalene-1-sulfonyl)piperidin-4-ol, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: rbp1, crbp1, retinol-binding, retinol, vitamin a, retinol-binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17264.75

構造登録者

Plau, J.,Golczak, M. (登録日: 2023-03-07, 公開日: 2023-10-04, 最終更新日: 2023-11-01)

• 主引用文献: Plau, J.,Morgan, C.E.,Fedorov, Y.,Banerjee, S.,Adams, D.J.,Blaner, W.S.,Yu, E.W.,Golczak, M.; Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms.; Acs Chem.Biol., 18:2309-2323, 2023; PubMed: 37713257; DOI: 10.1021/acschembio.3c00402

実験手法

X-RAY DIFFRACTION (1.3 Å)