8GEY
Crystal structure of human cellular retinol binding protein 1 in complex with 4-(hydroxymethyl)-1-[(4-methoxy-5,6,7,8-tetrahydronaphthalen-1-yl)sulfonyl]piperidin-4-ol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001523 | biological_process | retinoid metabolic process |
| B | 0002138 | biological_process | retinoic acid biosynthetic process |
| B | 0005501 | molecular_function | retinoid binding |
| B | 0005504 | molecular_function | fatty acid binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005829 | cellular_component | cytosol |
| B | 0006776 | biological_process | vitamin A metabolic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016918 | molecular_function | retinal binding |
| B | 0019841 | molecular_function | retinol binding |
| B | 0055088 | biological_process | lipid homeostasis |
| B | 0140104 | molecular_function | molecular carrier activity |
| B | 1904768 | molecular_function | all-trans-retinol binding |
Functional Information from PROSITE/UniProt
| site_id | PS00214 |
| Number of Residues | 18 |
| Details | FABP Cytosolic fatty-acid binding proteins signature. GYWkMlvNeNFEeYLRAL |
| Chain | Residue | Details |
| B | GLY6-LEU23 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Region: {"description":"Important for interaction with STRA6","evidences":[{"source":"PubMed","id":"22665496","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26900151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28057518","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26900151","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28057518","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
