8GD2

Crystal structure of human cellular retinol binding protein 1 in complex with N-methyl-1-{3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}-N-(2-thienylmethyl)methanamine

Summary for 8GD2

Entry DOI	10.2210/pdb8gd2/pdb
Descriptor	Retinol-binding protein 1, N-methyl-1-{3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}-N-[(thiophen-2-yl)methyl]methanamine, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
Functional Keywords	rbp1, crbp1, retinol-binding, retinol, vitamin a, retinol-binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	17276.81
Authors	Plau, J.,Golczak, M. (deposition date: 2023-03-03, release date: 2023-10-04, Last modification date: 2023-11-01)
Primary citation	Plau, J.,Morgan, C.E.,Fedorov, Y.,Banerjee, S.,Adams, D.J.,Blaner, W.S.,Yu, E.W.,Golczak, M. Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms. Acs Chem.Biol., 18:2309-2323, 2023 Cited by PubMed: 37713257 DOI: 10.1021/acschembio.3c00402 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.13 Å)

Structure validation