8GDM

Crystal structure of human cellular retinol binding protein 1 in complex with {[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl}(methyl)[1-(thiophen-2-yl)ethyl]amine

Summary for 8GDM

• Entry DOI: 10.2210/pdb8gdm/pdb
• Related: 8GD2
• Descriptor: Retinol-binding protein 1, (1S)-N-{[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl}-N-methyl-1-(thiophen-2-yl)ethan-1-amine (3 entities in total)
• Functional Keywords: rbp1, crbp1, retinol-binding, retinol, vitamin a, retinol-binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 17089.58

Authors

Plau, J.,Golczak, M. (deposition date: 2023-03-06, release date: 2023-10-04, Last modification date: 2023-11-01)

• Primary citation: Plau, J.,Morgan, C.E.,Fedorov, Y.,Banerjee, S.,Adams, D.J.,Blaner, W.S.,Yu, E.W.,Golczak, M.; Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms.; Acs Chem.Biol., 18:2309-2323, 2023; PubMed: 37713257; DOI: 10.1021/acschembio.3c00402

Experimental method

X-RAY DIFFRACTION (1.8 Å)