8G04

Structure of signaling thrombopoietin-MPL receptor complex

Summary for 8G04

Entry DOI	10.2210/pdb8g04/pdb
EMDB information	29644
Descriptor	Thrombopoietin, Thrombopoietin receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	tpo, tpor, cytokine, receptor, signaling, haematology
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	163776.40
Authors	Tsutsumi, N.,Jude, K.M.,Gati, C.,Garcia, K.C. (deposition date: 2023-01-31, release date: 2023-08-30, Last modification date: 2024-05-08)
Primary citation	Tsutsumi, N.,Masoumi, Z.,James, S.C.,Tucker, J.A.,Winkelmann, H.,Grey, W.,Picton, L.K.,Moss, L.,Wilson, S.C.,Caveney, N.A.,Jude, K.M.,Gati, C.,Piehler, J.,Hitchcock, I.S.,Garcia, K.C. Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell, 186:4189-4203.e22, 2023 Cited by PubMed: 37633268 DOI: 10.1016/j.cell.2023.07.037 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation