8FYY
Crystal structure of human PARP1 ART domain bound to inhibitor UKTT5 (compound 10)
Summary for 8FYY
Entry DOI | 10.2210/pdb8fyy/pdb |
Related | 8FYZ 8FZ1 8G0H |
Descriptor | Poly [ADP-ribose] polymerase 1, processed C-terminus, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, 2-(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-7-carboxamide, ... (6 entities in total) |
Functional Keywords | parp, adp-ribose transferase, dna binding protein, dna binding protein-inhibitor complex, dna binding protein/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 30954.28 |
Authors | Rouleau-Turcotte, E.,Pascal, J.M. (deposition date: 2023-01-27, release date: 2024-02-07, Last modification date: 2024-03-20) |
Primary citation | Velagapudi, U.K.,Rouleau-Turcotte, E.,Billur, R.,Shao, X.,Patil, M.,Black, B.E.,Pascal, J.M.,Talele, T.T. Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem.J., 481:437-460, 2024 Cited by PubMed: 38372302DOI: 10.1042/BCJ20230406 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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