8FY0
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)
Summary for 8FY0
Entry DOI | 10.2210/pdb8fy0/pdb |
Descriptor | von Hippel-Lindau disease tumor suppressor, Elongin-B, Elongin-C, ... (7 entities in total) |
Functional Keywords | ternary complex, degrader, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 72763.98 |
Authors | |
Primary citation | Nayak, D.,Lv, D.,Yuan, Y.,Zhang, P.,Hu, W.,Nayak, A.,Ruben, E.A.,Lv, Z.,Sung, P.,Hromas, R.,Zheng, G.,Zhou, D.,Olsen, S.K. Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15:2743-2743, 2024 Cited by PubMed: 38548768DOI: 10.1038/s41467-024-46922-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
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