8FSJ

Cryo-EM structure of engineered hepatitis C virus E1E2 ectodomain in complex with antibodies AR4A, HEPC74, and IGH520

Summary for 8FSJ

• Entry DOI: 10.2210/pdb8fsj/pdb
• EMDB information: 29419
• Descriptor: HCV E2 ectodomain, SYNZIP2 scaffold fusion, HEPC74 heavy chain, HEPC74 light chain, ... (9 entities in total)
• Functional Keywords: hcv, e1e2, viral protein
• Biological source: Hepacivirus C; More
• Total number of polymer chains: 6
• Total formula weight: 180343.45

Authors

Metcalf, M.C.,Ofek, G. (deposition date: 2023-01-10, release date: 2023-07-19)

• Primary citation: Metcalf, M.C.,Janus, B.M.,Yin, R.,Wang, R.,Guest, J.D.,Pozharski, E.,Law, M.,Mariuzza, R.A.,Toth, E.A.,Pierce, B.G.,Fuerst, T.R.,Ofek, G.; Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies.; Nat Commun, 14:3980-3980, 2023; PubMed: 37407593; DOI: 10.1038/s41467-023-39659-z

Experimental method

ELECTRON MICROSCOPY (3.65 Å)