8FSJ
Cryo-EM structure of engineered hepatitis C virus E1E2 ectodomain in complex with antibodies AR4A, HEPC74, and IGH520
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | HCV E2 ectodomain, SYNZIP2 scaffold fusion | polymer | 385 | 42975.4 | 1 | UniProt (A0A2P0NE15) Pfam (PF01560) | Hepacivirus C | |
| 2 | B (H) | HEPC74 heavy chain | polymer | 264 | 27644.8 | 1 | Homo sapiens (human) | ||
| 3 | C (L) | HEPC74 light chain | polymer | 214 | 23470.1 | 1 | Homo sapiens (human) | ||
| 4 | D (A) | HCV E1 ectodomain, SYNZIP1 scaffold fusion | polymer | 206 | 22951.4 | 1 | UniProt (A0A2P0NE34) Pfam (PF01539) UniProt (by SIFTS) (Q81387) | Hepacivirus C | |
| 5 | E (B) | AR4A light chain | polymer | 236 | 25743.8 | 1 | Homo sapiens (human) | ||
| 6 | F (C) | AR4A heavy chain | polymer | 298 | 31862.7 | 1 | Homo sapiens (human) | ||
| 7 | G, H (D, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 8 | I, J, K, L, M... (G, I, J, K, M...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G15407YE) | |||
| 9 | O, P, Q, R, S... (E, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
E: 384 - 714 (UniProt: A0A2P0NE15)
E: 715 - 768 (PDB: 8FSJ)
A: 192 - 349 (UniProt: A0A2P0NE34)
A: 350 - 397 (PDB: 8FSJ)
E: 715 - 768 (PDB: 8FSJ)
A: 192 - 349 (UniProt: A0A2P0NE34)
A: 350 - 397 (PDB: 8FSJ)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 174648.1 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 4368.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 180343.4 |
