8FPG
GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg)
Summary for 8FPG
Entry DOI | 10.2210/pdb8fpg/pdb |
EMDB information | 29360 29361 29363 29364 29367 29368 |
Descriptor | Voltage-dependent calcium channel gamma-2 subunit, Glutamate receptor 2, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | ionotropic glutamate receptors, ampa receptors, ion channel, ligand-gated ion channel, auxiliary subunit, stargazing, tarp gamma2, transport protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 8 |
Total formula weight | 546818.89 |
Authors | Nakagawa, T. (deposition date: 2023-01-04, release date: 2024-02-28, Last modification date: 2024-05-01) |
Primary citation | Nakagawa, T.,Wang, X.T.,Miguez-Cabello, F.J.,Bowie, D. The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31:688-700, 2024 Cited by PubMed: 38409505DOI: 10.1038/s41594-024-01228-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.32 Å) |
Structure validation
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