8FPG
GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H, F, E, G | Voltage-dependent calcium channel gamma-2 subunit | polymer | 336 | 37109.8 | 4 | UniProt (O88602) Pfam (PF00822) In PDB | Mus musculus (house mouse) | Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2 |
2 | C, B, A, D | Glutamate receptor 2 | polymer | 889 | 99559.5 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
3 | H, F, E, G | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
4 | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
H, F, E, G: 1 - 323 (UniProt: O88602)
C, B, A, D: -20 - 868 (UniProt: P19491)
PDB | External Database | Details |
---|---|---|
Glu 52 | Lys 52 | engineered mutation |
Glu 53 | Lys 53 | engineered mutation |
Gly 324 | - | expression tag |
Gly 325 | - | expression tag |
Arg 326 | - | expression tag |
Gly 327 | - | expression tag |
Gly 328 | - | expression tag |
Thr 329 | - | expression tag |
Glu 330 | - | expression tag |
Thr 331 | - | expression tag |
Ser 332 | - | expression tag |
Gln 333 | - | expression tag |
Ala 334 | - | expression tag |
Pro 335 | - | expression tag |
Ala 336 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp 848 | - | insertion |
Tyr 849 | - | insertion |
Lys 850 | - | insertion |
Asp 851 | - | insertion |
Asp 852 | - | insertion |
Asp 853 | - | insertion |
Asp 854 | Tyr 869 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 546677.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 141.8 | |
All* | Total formula weight | 546818.9 |