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8FPG

GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg)

Functional Information from GO Data
ChainGOidnamespacecontents
E0005245molecular_functionvoltage-gated calcium channel activity
E0005262molecular_functioncalcium channel activity
E0005515molecular_functionprotein binding
E0006612biological_processprotein targeting to membrane
E0007528biological_processneuromuscular junction development
E0009986cellular_componentcell surface
E0016020cellular_componentmembrane
E0016247molecular_functionchannel regulator activity
E0019226biological_processtransmission of nerve impulse
E0032281cellular_componentAMPA glutamate receptor complex
E0034702cellular_componentmonoatomic ion channel complex
E0035255molecular_functionionotropic glutamate receptor binding
E0036477cellular_componentsomatodendritic compartment
E0042391biological_processregulation of membrane potential
E0043005cellular_componentneuron projection
E0044300cellular_componentcerebellar mossy fiber
E0045202cellular_componentsynapse
E0050877biological_processnervous system process
E0051592biological_processresponse to calcium ion
E0051899biological_processmembrane depolarization
E0051968biological_processpositive regulation of synaptic transmission, glutamatergic
E0060081biological_processmembrane hyperpolarization
E0060082biological_processeye blink reflex
E0070588biological_processcalcium ion transmembrane transport
E0098685cellular_componentSchaffer collateral - CA1 synapse
E0098686cellular_componenthippocampal mossy fiber to CA3 synapse
E0098839cellular_componentpostsynaptic density membrane
E0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
E0098962biological_processregulation of postsynaptic neurotransmitter receptor activity
E0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
E0098978cellular_componentglutamatergic synapse
E0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
E0099590biological_processneurotransmitter receptor internalization
E0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
E1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
E2000311biological_processregulation of AMPA receptor activity
F0005245molecular_functionvoltage-gated calcium channel activity
F0005262molecular_functioncalcium channel activity
F0005515molecular_functionprotein binding
F0006612biological_processprotein targeting to membrane
F0007528biological_processneuromuscular junction development
F0009986cellular_componentcell surface
F0016020cellular_componentmembrane
F0016247molecular_functionchannel regulator activity
F0019226biological_processtransmission of nerve impulse
F0032281cellular_componentAMPA glutamate receptor complex
F0034702cellular_componentmonoatomic ion channel complex
F0035255molecular_functionionotropic glutamate receptor binding
F0036477cellular_componentsomatodendritic compartment
F0042391biological_processregulation of membrane potential
F0043005cellular_componentneuron projection
F0044300cellular_componentcerebellar mossy fiber
F0045202cellular_componentsynapse
F0050877biological_processnervous system process
F0051592biological_processresponse to calcium ion
F0051899biological_processmembrane depolarization
F0051968biological_processpositive regulation of synaptic transmission, glutamatergic
F0060081biological_processmembrane hyperpolarization
F0060082biological_processeye blink reflex
F0070588biological_processcalcium ion transmembrane transport
F0098685cellular_componentSchaffer collateral - CA1 synapse
F0098686cellular_componenthippocampal mossy fiber to CA3 synapse
F0098839cellular_componentpostsynaptic density membrane
F0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
F0098962biological_processregulation of postsynaptic neurotransmitter receptor activity
F0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
F0098978cellular_componentglutamatergic synapse
F0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
F0099590biological_processneurotransmitter receptor internalization
F0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
F1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
F2000311biological_processregulation of AMPA receptor activity
G0005245molecular_functionvoltage-gated calcium channel activity
G0005262molecular_functioncalcium channel activity
G0005515molecular_functionprotein binding
G0006612biological_processprotein targeting to membrane
G0007528biological_processneuromuscular junction development
G0009986cellular_componentcell surface
G0016020cellular_componentmembrane
G0016247molecular_functionchannel regulator activity
G0019226biological_processtransmission of nerve impulse
G0032281cellular_componentAMPA glutamate receptor complex
G0034702cellular_componentmonoatomic ion channel complex
G0035255molecular_functionionotropic glutamate receptor binding
G0036477cellular_componentsomatodendritic compartment
G0042391biological_processregulation of membrane potential
G0043005cellular_componentneuron projection
G0044300cellular_componentcerebellar mossy fiber
G0045202cellular_componentsynapse
G0050877biological_processnervous system process
G0051592biological_processresponse to calcium ion
G0051899biological_processmembrane depolarization
G0051968biological_processpositive regulation of synaptic transmission, glutamatergic
G0060081biological_processmembrane hyperpolarization
G0060082biological_processeye blink reflex
G0070588biological_processcalcium ion transmembrane transport
G0098685cellular_componentSchaffer collateral - CA1 synapse
G0098686cellular_componenthippocampal mossy fiber to CA3 synapse
G0098839cellular_componentpostsynaptic density membrane
G0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
G0098962biological_processregulation of postsynaptic neurotransmitter receptor activity
G0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
G0098978cellular_componentglutamatergic synapse
G0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
G0099590biological_processneurotransmitter receptor internalization
G0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
G1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
G2000311biological_processregulation of AMPA receptor activity
H0005245molecular_functionvoltage-gated calcium channel activity
H0005262molecular_functioncalcium channel activity
H0005515molecular_functionprotein binding
H0006612biological_processprotein targeting to membrane
H0007528biological_processneuromuscular junction development
H0009986cellular_componentcell surface
H0016020cellular_componentmembrane
H0016247molecular_functionchannel regulator activity
H0019226biological_processtransmission of nerve impulse
H0032281cellular_componentAMPA glutamate receptor complex
H0034702cellular_componentmonoatomic ion channel complex
H0035255molecular_functionionotropic glutamate receptor binding
H0036477cellular_componentsomatodendritic compartment
H0042391biological_processregulation of membrane potential
H0043005cellular_componentneuron projection
H0044300cellular_componentcerebellar mossy fiber
H0045202cellular_componentsynapse
H0050877biological_processnervous system process
H0051592biological_processresponse to calcium ion
H0051899biological_processmembrane depolarization
H0051968biological_processpositive regulation of synaptic transmission, glutamatergic
H0060081biological_processmembrane hyperpolarization
H0060082biological_processeye blink reflex
H0070588biological_processcalcium ion transmembrane transport
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098686cellular_componenthippocampal mossy fiber to CA3 synapse
H0098839cellular_componentpostsynaptic density membrane
H0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
H0098962biological_processregulation of postsynaptic neurotransmitter receptor activity
H0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
H0098978cellular_componentglutamatergic synapse
H0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
H0099590biological_processneurotransmitter receptor internalization
H0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
H1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
H2000311biological_processregulation of AMPA receptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2780
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
CVAL1-ALA522
ESER104-ALA124
EILE134-ILE154
EPHE182-ILE202
GMET10-THR30
GSER104-ALA124
GILE134-ILE154
GPHE182-ILE202
CTHR617-ASN791
BVAL1-ALA522
BTHR617-ASN791
AVAL1-ALA522
ATHR617-ASN791
DVAL1-ALA522
DTHR617-ASN791
EMET10-THR30

site_idSWS_FT_FI2
Number of Residues160
DetailsTRANSMEM: Helical
ChainResidueDetails
CTYR523-VAL543
CLEU596-TYR616
BTYR523-VAL543
BLEU596-TYR616
ATYR523-VAL543
ALEU596-TYR616
DTYR523-VAL543
DLEU596-TYR616

site_idSWS_FT_FI3
Number of Residues320
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
CSER544-GLU570
DSER544-GLU570
DASP590-SER595
DGLU813-GLY862
CASP590-SER595
CGLU813-GLY862
BSER544-GLU570
BASP590-SER595
BGLU813-GLY862
ASER544-GLU570
AASP590-SER595
AGLU813-GLY862

site_idSWS_FT_FI4
Number of Residues60
DetailsINTRAMEM: Helical; Pore-forming
ChainResidueDetails
CPHE571-GLN586
BPHE571-GLN586
APHE571-GLN586
DPHE571-GLN586

site_idSWS_FT_FI5
Number of Residues8
DetailsINTRAMEM:
ChainResidueDetails
CGLN587-CYS589
BGLN587-CYS589
AGLN587-CYS589
DGLN587-CYS589

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=M4
ChainResidueDetails
CVAL792-ILE812
BVAL792-ILE812
AVAL792-ILE812
DVAL792-ILE812

site_idSWS_FT_FI7
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:16483599
ChainResidueDetails
CTYR450
DTYR450
DARG485
DGLU705
CARG485
CGLU705
BTYR450
BARG485
BGLU705
ATYR450
AARG485
AGLU705

site_idSWS_FT_FI8
Number of Residues4
DetailsBINDING:
ChainResidueDetails
CPRO478
BPRO478
APRO478
DPRO478

site_idSWS_FT_FI9
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:25103405
ChainResidueDetails
CTHR480
DTHR480
DSER654
DTHR655
CSER654
CTHR655
BTHR480
BSER654
BTHR655
ATHR480
ASER654
ATHR655

site_idSWS_FT_FI10
Number of Residues12
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
CARG453
DARG453
DARG660
DLYS752
CARG660
CLYS752
BARG453
BARG660
BLYS752
AARG453
AARG660
ALYS752

site_idSWS_FT_FI11
Number of Residues4
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
CILE633
BILE633
AILE633
DILE633

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails
CSER662
BSER662
ASER662
DSER662

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails
CSER696
BSER696
ASER696
DSER696

site_idSWS_FT_FI14
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23819
ChainResidueDetails
CSER839
DSER839
DSER842
DSER865
CSER842
CSER865
BSER839
BSER842
ASER839
ASER842
ASER865
BSER865

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15240807, ECO:0000269|PubMed:20547133
ChainResidueDetails
CTYR861
BTYR861
ATYR861
DTYR861

site_idSWS_FT_FI16
Number of Residues8
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
CCYS589
CCYS815
BCYS589
BCYS815
ACYS589
ACYS815
DCYS589
DCYS815

site_idSWS_FT_FI17
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873
ChainResidueDetails
CASN235
BASN235
AASN235
DASN235

site_idSWS_FT_FI18
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405
ChainResidueDetails
CASN349
BASN349
AASN349
DASN349

site_idSWS_FT_FI19
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN385
CASN392
BASN385
BASN392
AASN385
AASN392
DASN385
DASN392

219869

PDB entries from 2024-05-15

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