8FM5

HIV-1 gp120 complex with DY-III-065

Summary for 8FM5

Entry DOI	10.2210/pdb8fm5/pdb
Related	8FLY 8FLZ 8FM0 8FM2 8FM3 8FM4
Descriptor	Envelope glycoprotein gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,3,3-trifluoropropyl (2R,3S)-2-(carbamimidamidomethyl)-3-[2-(4-chloro-3-fluoroanilino)(oxo)acetamido]-6-[(methylamino)methyl]-2,3-dihydro-1H-indole-1-carboxylate, ... (4 entities in total)
Functional Keywords	retrovirus, gp120, entry inhibitor, structure-based drug design, small molecule, antiretroviral therapy, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	HIV-1 06TG.HT008
Total number of polymer chains	4
Total formula weight	167125.88
Authors	Gong, Z.,Hendrickson, W.A. (deposition date: 2022-12-22, release date: 2023-04-05)
Primary citation	Fritschi, C.J.,Anang, S.,Gong, Z.,Mohammadi, M.,Richard, J.,Bourassa, C.,Severino, K.T.,Richter, H.,Yang, D.,Chen, H.C.,Chiu, T.J.,Seaman, M.S.,Madani, N.,Abrams, C.,Finzi, A.,Hendrickson, W.A.,Sodroski, J.G.,Smith III, A.B. Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proc.Natl.Acad.Sci.USA, 120:e2222073120-e2222073120, 2023 Cited by PubMed: 36961924 DOI: 10.1073/pnas.2222073120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation