8FJI

Crystal structure of RalA in a covalent complex with SOF-367

Summary for 8FJI

• Entry DOI: 10.2210/pdb8fji/pdb
• Descriptor: Ras-related protein Ral-A, GUANOSINE-5'-DIPHOSPHATE, 8-[fluoro(dihydroxy)-lambda~4~-sulfanyl]-N-(2-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxine-5-sulfonamide, ... (5 entities in total)
• Functional Keywords: rala, gtpase, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 22271.67

Authors

Landgraf, A.D.,Yeh, I.-J.,Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S. (deposition date: 2022-12-19, release date: 2023-12-06)

• Primary citation: Landgraf, A.D.,Yeh, I.J.,Ghozayel, M.K.,Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S.O.; Exploring Covalent Bond Formation at Tyr-82 for Inhibition of Ral GTPase Activation.; Chemmedchem, 18:e202300272-e202300272, 2023; PubMed: 37269475; DOI: 10.1002/cmdc.202300272

Experimental method

X-RAY DIFFRACTION (1.48 Å)