8FHQ
Cryo-EM structure of human NCC (class 3-2)
Summary for 8FHQ
Entry DOI | 10.2210/pdb8fhq/pdb |
EMDB information | 29099 |
Descriptor | Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera, Polythiazide, SODIUM ION (3 entities in total) |
Functional Keywords | membrane transporter, membrane protein |
Biological source | Danio rerio (Zebrafish, Brachydanio rerio) More |
Total number of polymer chains | 2 |
Total formula weight | 241670.07 |
Authors | |
Primary citation | Fan, M.,Zhang, J.,Lee, C.L.,Zhang, J.,Feng, L. Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter. Nature, 614:788-793, 2023 Cited by PubMed: 36792826DOI: 10.1038/s41586-023-05718-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.81 Å) |
Structure validation
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