8FGX
Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein
Summary for 8FGX
Entry DOI | 10.2210/pdb8fgx/pdb |
EMDB information | 29077 |
Descriptor | STAR-0215 Light chain, STAR-0215 Heavy chain, Plasma kallikrein light chain, ... (4 entities in total) |
Functional Keywords | plasma kallikrein, plasma prekallikrein, fletcher factor, hereditary angioedema, hae, kininogenin, c1-inh, bradykinin, hydrolase-immune system complex, hydrolase/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 117240.32 |
Authors | Fuller, J.R.,Biris, N.,Bista, P. (deposition date: 2022-12-13, release date: 2023-09-06, Last modification date: 2023-10-25) |
Primary citation | Bedian, V.,Biris, N.,Omer, C.,Chung, J.K.,Fuller, J.,Dagher, R.,Chandran, S.,Harwin, P.,Kiselak, T.,Violin, J.,Nichols, A.,Bista, P. STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema. J.Pharmacol.Exp.Ther., 387:214-225, 2023 Cited by PubMed: 37643795DOI: 10.1124/jpet.123.001740 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.62 Å) |
Structure validation
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