8FE4

Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody

Summary for 8FE4

Entry DOI	10.2210/pdb8fe4/pdb
EMDB information	29021
Descriptor	Envelope protein E, prM protein, prM13 Fab Heavy Chain, ... (4 entities in total)
Functional Keywords	denv, flavivirus, prm antibody, prm13, virus-immune system complex, virus/immune system
Biological source	Dengue virus type 2 More
Total number of polymer chains	12
Total formula weight	300531.50
Authors	Dowd, A.D.,Sirohi, D.,Speer, S.,Mukherjee, S.,Govero, J.,Aleshnick, M.,Larman, B.,Sukupolvi-Petty, S.,Sevvana, M.,Miller, A.S.,Klose, T.,Zheng, A.,Kielian, M.,Kuhn, R.J.,Diamond, M.S.,Pierson, T.C. (deposition date: 2022-12-05, release date: 2023-02-01, Last modification date: 2023-04-05)
Primary citation	A Dowd, K.,Sirohi, D.,D Speer, S.,VanBlargan, L.A.,Chen, R.E.,Mukherjee, S.,Whitener, B.M.,Govero, J.,Aleshnick, M.,Larman, B.,Sukupolvi-Petty, S.,Sevvana, M.,Miller, A.S.,Klose, T.,Zheng, A.,Koenig, S.,Kielian, M.,Kuhn, R.J.,Diamond, M.S.,Pierson, T.C. prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis. Proc.Natl.Acad.Sci.USA, 120:e2218899120-e2218899120, 2023 Cited by PubMed: 36638211 DOI: 10.1073/pnas.2218899120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (9.8 Å)

Structure validation