8FD7
Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin
Summary for 8FD7
Entry DOI | 10.2210/pdb8fd7/pdb |
EMDB information | 29004 29006 29007 29015 |
Descriptor | Voltage-dependent calcium channel subunit alpha-2/delta-1, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, CHOLESTEROL, ... (12 entities in total) |
Functional Keywords | voltage-gated calcium channel, cav alpha2delta, drug binding, gabapentin, membrane protein |
Biological source | Oryctolagus cuniculus (rabbit) More |
Total number of polymer chains | 3 |
Total formula weight | 370952.36 |
Authors | Chen, Z.,Mondal, A.,Minor, D.L. (deposition date: 2022-12-02, release date: 2023-03-22, Last modification date: 2023-07-05) |
Primary citation | Chen, Z.,Mondal, A.,Minor Jr., D.L. Structural basis for Ca V alpha 2 delta :gabapentin binding. Nat.Struct.Mol.Biol., 30:735-739, 2023 Cited by PubMed: 36973510DOI: 10.1038/s41594-023-00951-7 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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