8FD7
Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1105 | 125082.9 | 1 | UniProt (P13806) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) | Oryctolagus cuniculus (rabbit) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 2 | B (K) | Voltage-dependent L-type calcium channel subunit alpha-1C | polymer | 1648 | 187082.2 | 1 | UniProt (Q13936) Pfam (PF00520) Pfam (PF16905) Pfam (PF08763) | Homo sapiens (human) | Calcium channel,L type,alpha-1 polypeptide,isoform 1,cardiac muscle,Voltage-gated calcium channel subunit alpha Cav1.2 |
| 3 | C (C) | Voltage-dependent L-type calcium channel subunit beta-3 | polymer | 477 | 53889.2 | 1 | UniProt (P54286) Pfam (PF12052) Pfam (PF00625) | Oryctolagus cuniculus (rabbit) | CAB3,Calcium channel voltage-dependent subunit beta 3 |
| 4 | D (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E, G, H, I, J... (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 6 | F (D) | [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID | non-polymer | 171.2 | 1 | Chemie (GBN) PubChem (3446) | |||
| 7 | N, U, V (D, K) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) PubChem (271) | |||
| 8 | O (D) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 9 | P (K) | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate | non-polymer | 649.9 | 1 | Chemie (WO9) PubChem (52924242) PubChem (134781349) | |||
| 10 | Q (K) | (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate | non-polymer | 579.7 | 1 | Chemie (YSW) PubChem (108390) PubChem (97044991) PubChem (9546801) | |||
| 11 | R, S, T (K) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (45044259) PubChem (23423981) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (191463) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (368063) PubChem (369319) PubChem (44654663) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (46937002) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (638019) PubChem (59274407) PubChem (1549081) PubChem (1553803) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (89951918) PubChem (90224410) PubChem (5997) PubChem (5283629) PubChem (5284644) PubChem (1551269) PubChem (90070115) PubChem (91298236) PubChem (5315842) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (6419195) PubChem (10861996) PubChem (132837164) PubChem (101624109) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (124225449) PubChem (138967089) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (139566851) PubChem (124429284) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (15939944) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (171828367) PubChem (173516975) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 12 | W (K) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
D: 1 - 1105 (UniProt: P13806)
| PDB | External Database | Details |
|---|---|---|
| - | Ser 620 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 366054.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 4473.7 | |
| All* | Total formula weight | 370952.4 |
