Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8FD7

Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005245	molecular_function	voltage-gated calcium channel activity
C	0005246	molecular_function	calcium channel regulator activity
C	0005262	molecular_function	calcium channel activity
C	0005737	cellular_component	cytoplasm
C	0005891	cellular_component	voltage-gated calcium channel complex
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0061577	biological_process	calcium ion transmembrane transport via high voltage-gated calcium channel
C	0070588	biological_process	calcium ion transmembrane transport
C	1901843	biological_process	positive regulation of high voltage-gated calcium channel activity
C	1990454	cellular_component	L-type voltage-gated calcium channel complex
K	0005216	molecular_function	monoatomic ion channel activity
K	0005245	molecular_function	voltage-gated calcium channel activity
K	0005891	cellular_component	voltage-gated calcium channel complex
K	0006811	biological_process	monoatomic ion transport
K	0016020	cellular_component	membrane
K	0055085	biological_process	transmembrane transport
K	0070588	biological_process	calcium ion transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	177
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	91
Details	Domain: {"description":"Cache"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Motif: {"description":"MIDAS-like motif"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54290","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	11
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	263
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	144
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	80
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	17
Details	Region: {"description":"AID/alpha-interaction domain; mediates interaction with the beta subunit","evidences":[{"source":"PubMed","id":"15141227","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	157
Details	Region: {"description":"Dihydropyridine binding","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	42
Details	Region: {"description":"Phenylalkylamine binding","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	3
Details	Motif: {"description":"Selectivity filter of repeat I","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	3
Details	Motif: {"description":"Selectivity filter of repeat II","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	3
Details	Motif: {"description":"Selectivity filter of repeat III","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	3
Details	Motif: {"description":"Selectivity filter of repeat IV","evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P07293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	3
Details	Site: {"description":"Calcium ion selectivity and permeability","evidences":[{"source":"PubMed","id":"8099908","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	150
Details	Region: {"description":"Mediates interaction with the alpha subunit","evidences":[{"source":"UniProtKB","id":"P54287","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)