8FCA

Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate

8FCA の概要

• エントリーDOI: 10.2210/pdb8fca/pdb
• EMDBエントリー: 28978
• 分子名称: Transient receptor potential cation channel subfamily V member 4, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE (3 entities in total)
• 機能のキーワード: trpv4, rhoa, 4alpha-phorbol 12, 13-didecanoate, 4a-pdd, membrane protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 412869.82

構造登録者

Kwon, D.H.,Lee, S.-Y.,Zhang, F. (登録日: 2022-12-01, 公開日: 2023-07-12, 最終更新日: 2024-06-19)

• 主引用文献: Kwon, D.H.,Zhang, F.,McCray, B.A.,Feng, S.,Kumar, M.,Sullivan, J.M.,Im, W.,Sumner, C.J.,Lee, S.Y.; TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.; Nat Commun, 14:3732-3732, 2023; PubMed: 37353484; DOI: 10.1038/s41467-023-39345-0

実験手法

ELECTRON MICROSCOPY (3.41 Å)