8FC8
Cryo-EM structure of the human TRPV4 in complex with GSK1016790A
Summary for 8FC8
Entry DOI | 10.2210/pdb8fc8/pdb |
EMDB information | 28976 29331 29332 |
Descriptor | Transient receptor potential cation channel subfamily V member 4, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, CHOLESTEROL HEMISUCCINATE (3 entities in total) |
Functional Keywords | trpv4, rhoa, gsk1016790a, membrane protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 412800.54 |
Authors | Kwon, D.H.,Lee, S.-Y.,Zhang, F. (deposition date: 2022-12-01, release date: 2023-07-12, Last modification date: 2024-06-19) |
Primary citation | Kwon, D.H.,Zhang, F.,McCray, B.A.,Feng, S.,Kumar, M.,Sullivan, J.M.,Im, W.,Sumner, C.J.,Lee, S.Y. TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14:3732-3732, 2023 Cited by PubMed: 37353484DOI: 10.1038/s41467-023-39345-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.47 Å) |
Structure validation
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