8FC7

Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745

8FC7 の概要

• エントリーDOI: 10.2210/pdb8fc7/pdb
• EMDBエントリー: 28975 29030 29031
• 分子名称: Transient receptor potential cation channel subfamily V member 4, Transforming protein RhoA, 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, ... (5 entities in total)
• 機能のキーワード: trpv4, rhoa, gsk2798745, membrane protein, membrane protein-hydrolase complex, membrane protein/hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 499139.96

構造登録者

Kwon, D.H.,Lee, S.-Y.,Zhang, F. (登録日: 2022-12-01, 公開日: 2023-07-12, 最終更新日: 2024-06-19)

• 主引用文献: Kwon, D.H.,Zhang, F.,McCray, B.A.,Feng, S.,Kumar, M.,Sullivan, J.M.,Im, W.,Sumner, C.J.,Lee, S.Y.; TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.; Nat Commun, 14:3732-3732, 2023; PubMed: 37353484; DOI: 10.1038/s41467-023-39345-0

実験手法