8FC6
Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.35A resolution
This is a non-PDB format compatible entry.
Summary for 8FC6
Entry DOI | 10.2210/pdb8fc6/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total) |
Functional Keywords | hygromycin a; macrolides; ketolides; erythromycin; azithromycin; telithromycin; antibiotic; synergy; erm methyltransferase, x-ray structure; 70s ribosome; peptidyl transferase center; nascent peptide exit tunnel, ribosome |
Biological source | Escherichia coli More |
Total number of polymer chains | 106 |
Total formula weight | 4428571.98 |
Authors | Chen, C.-W.,Syroegin, E.A.,Svetlov, M.S.,Polikanov, Y.S. (deposition date: 2022-12-01, release date: 2023-07-26) |
Primary citation | Chen, C.W.,Leimer, N.,Syroegin, E.A.,Dunand, C.,Bulman, Z.P.,Lewis, K.,Polikanov, Y.S.,Svetlov, M.S. Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A. Nat Commun, 14:4196-4196, 2023 Cited by PubMed: 37452045DOI: 10.1038/s41467-023-39653-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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