8F8W

Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form I

8F8W の概要

• エントリーDOI: 10.2210/pdb8f8w/pdb
• 分子名称: afucosylated IgG1 fragment, Nb.X0, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: nanobody, glycobiology, immunoglobulin, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 159122.01

構造登録者

Goldgur, Y.,Ravetch, J.,Gupta, A.,Kao, K.,Oren, D. (登録日: 2022-11-22, 公開日: 2023-03-29, 最終更新日: 2023-10-11)

• 主引用文献: Gupta, A.,Kao, K.S.,Yamin, R.,Oren, D.A.,Goldgur, Y.,Du, J.,Lollar, P.,Sundberg, E.J.,Ravetch, J.V.; Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody.; Nat Commun, 14:2853-2853, 2023; PubMed: 37202422; DOI: 10.1038/s41467-023-38453-1

実験手法

X-RAY DIFFRACTION (2.71 Å)