8F5S

human branched chain ketoacid dehydrogenase kinase in complex with inhibitors

Summary for 8F5S

• Entry DOI: 10.2210/pdb8f5s/pdb
• Related: 8F5F
• Descriptor: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: branched chain ketoacid dehydrogenase kinase, inhibitor, signaling protein, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 90516.40

Authors

Liu, S.,Roth Flach, R.,Bollinger, E.,Filipski, K. (deposition date: 2022-11-15, release date: 2023-07-05, Last modification date: 2023-08-23)

• Primary citation: Roth Flach, R.J.,Bollinger, E.,Reyes, A.R.,Laforest, B.,Kormos, B.L.,Liu, S.,Reese, M.R.,Martinez Alsina, L.A.,Buzon, L.,Zhang, Y.,Bechle, B.,Rosado, A.,Sahasrabudhe, P.V.,Knafels, J.,Bhattacharya, S.K.,Omoto, K.,Stansfield, J.C.,Hurley, L.D.,Song, L.,Luo, L.,Breitkopf, S.B.,Monetti, M.,Cunio, T.,Tierney, B.,Geoly, F.J.,Delmore, J.,Siddall, C.P.,Xue, L.,Yip, K.N.,Kalgutkar, A.S.,Miller, R.A.,Zhang, B.B.,Filipski, K.J.; Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.; Nat Commun, 14:4812-4812, 2023; PubMed: 37558654; DOI: 10.1038/s41467-023-40536-y

Experimental method

X-RAY DIFFRACTION (2.793 Å)