8F5S
human branched chain ketoacid dehydrogenase kinase in complex with inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | polymer | 388 | 44251.6 | 2 | UniProt (O14874) Pfam (PF10436) Pfam (PF02518) | Homo sapiens (human) | Branched-chain alpha-ketoacid dehydrogenase kinase,BCKD-kinase,BCKDHKIN |
| 2 | C, K (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 3 | D, L (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | F, M (A, B) | (2M)-2-[2-(4-methylphenyl)-1,3-thiazol-4-yl]benzoic acid | non-polymer | 295.4 | 2 | Chemie (XGT) | |||
| 6 | G, H, I, J, N (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 7 | O, P (A, B) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 382 (UniProt: O14874)
| PDB | External Database | Details |
|---|---|---|
| His 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 88503.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2013.1 | |
| All* | Total formula weight | 90516.4 |
