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8EX0

Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with CDK2-IV

Summary for 8EX0
Entry DOI10.2210/pdb8ex0/pdb
DescriptorTyrosine-protein kinase JAK2, 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide (3 entities in total)
Functional Keywordsjanus tyrosine kinase, jak2, pseudokinase, phosphorylation, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight33543.48
Authors
Sampathkumar, P.,Hubbard, S.R. (deposition date: 2022-10-24, release date: 2023-02-01, Last modification date: 2024-05-22)
Primary citationVirtanen, A.T.,Haikarainen, T.,Sampathkumar, P.,Palmroth, M.,Liukkonen, S.,Liu, J.,Nekhotiaeva, N.,Hubbard, S.R.,Silvennoinen, O.
Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16:-, 2023
Cited by
PubMed: 36678572
DOI: 10.3390/ph16010075
PDB entries with the same primary citation
Experimental method
Structure validation

223790

건을2024-08-14부터공개중

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